Predictive Modeling Of Drug Sensitivity

Author: Ranadip Pal
Publisher: Academic Press
ISBN: 012805431X
Size: 60.12 MB
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This book is an ideal reference for computer scientists, engineers, computational biologists, and mathematicians who want to understand and apply multiple approaches and methods to drug sensitivity modeling.

British Journal Of Neurosurgery

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We conclude that different in vitro tumour clonogenic assays show different
colony-forming efficiencies for the same cell line and may show different
responses to certain drugs. Identification of accurate predictive models of drug
sensitivity will require correlative in vivo and in vitro studies. Key words:
Clonogenic assay, brain tumour, chemotherapy. Introduction There are two
fundamental problems facing the routine use of clonogenic assays to test the
sensitivity of human tumours to ...

Comprehensive Systems Biomedicine

Author: Pietro Lio
Publisher: Frontiers E-books
ISBN: 2889193748
Size: 80.53 MB
Format: PDF, ePub
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drug. action. Dušica Vidovi ́c1, Amar Koleti1 and Stephan C. Schürer1,2* 1
Center for Computational Science, University of Miami, Miami, FL, USA 2
Department of Molecular and Cellular Pharmacology, University of Miami, Miami,
FL, USA Edited by: Pietro Lio, University of Cambridge, UK Reviewed by: Yaoqi
Zhou, ... To fill gaps in the datasets we developed and applied predictive models.
... To deconvolute, model, and understand drug sensitivity relies on systems-wide
approaches ...

Translational Pain Research

Author: Lawrence Kruger
Publisher: CRC Press
ISBN: 1439812101
Size: 41.55 MB
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... important in the field of drug discovery and development since the sensitivity
and predictive validity of animal models can only be established through
extensive testing in many contexts. For these reasons, the rat and mouse models
will continue to be the workhorses driving basic research as well as drug
discovery. Unfortunately, there are 371 Chapter 17. Large Animal Models for
Pain Therapeutic Development.

Antimalarial Chemotherapy

Author: Philip J. Rosenthal
Publisher: Springer Science & Business Media
ISBN: 1592591116
Size: 40.17 MB
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Mechanisms of Action, Resistance, and New Directions in Drug Discovery Philip
J. Rosenthal. 11. 12. 13. 14. 15. 16. 17. 18. 19. 20. 21. 22. 23. 24. ... The efficacy
of antifolate antimalarial combinations in Africa: a predictive model based on
pharmacodynamic and pharmacokientic analyses. Parasitol Today 1997;13(12):
459–464. ... Le Bras J, Deloron P. In vitor study of drug sensitivity of Plasmodium
falciparum: evaluation of a new semi-micro test. Am J Trop Med Hyg 1983:32:447

Pharmacokinetics And Pharmacodynamics Of Abused Drugs

Author: Steven B. Karch, MD, FFFLM
Publisher: CRC Press
ISBN: 9781420054606
Size: 23.27 MB
Format: PDF, ePub, Mobi
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These parameters were then used to calculate several measures of predictive
accuracy of the DEC evaluation, including sensitivity, specificity, and efficiency. In
Study 1, the stepwise discriminant analysis resulted in a subset of 17 variables
that were the best predictors of ethanol. The discriminant function comprising
these 17 variables predicted the presence or absence of ethanol with extremely
high accuracy. The model was equally accurate in predicting the presence (
sensitivity ...

Predictive Modeling Of Pharmaceutical Unit Operations

Author: Preetanshu Pandey
Publisher: Woodhead Publishing
ISBN: 0081001800
Size: 63.72 MB
Format: PDF
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This book focuses on modeling and simulation tools as they pertain to drug product manufacturing processes, although similar principles and tools may apply to many other areas.